Opened 20 months ago
Closed 20 months ago
#1469 closed defect (fixed)
Update VarDict to version 1.8.3
Reported by: | Nicklas Nordborg | Owned by: | Nicklas Nordborg |
---|---|---|---|
Priority: | major | Milestone: | Reggie v4.45.1 |
Component: | net.sf.basedb.reggie | Keywords: | |
Cc: |
Description
The Variant calling script crashed due to a bug in VarDict:
There was Exception while processing cigar on 25001501 53M1I1M1I2M1D3M1I34M on region chr4:25001557-25001563. The processing will be continued from the next cigar. java.lang.StringIndexOutOfBoundsException: String index out of range: 111 at java.base/java.lang.StringLatin1.charAt(StringLatin1.java:47) at java.base/java.lang.String.charAt(String.java:693) at com.astrazeneca.vardict.variations.VariationUtils.isHasAndNotEquals(VariationUtils.java:498) at com.astrazeneca.vardict.modules.CigarModifier.captureMisSoftly3Mismatches(CigarModifier.java:320) at com.astrazeneca.vardict.modules.CigarModifier.modifyCigar(CigarModifier.java:178) at com.astrazeneca.vardict.modules.CigarParser.parseCigar(CigarParser.java:270) at com.astrazeneca.vardict.modules.CigarParser.process(CigarParser.java:89) at java.base/java.util.concurrent.CompletableFuture.uniApplyNow(CompletableFuture.java:680) at java.base/java.util.concurrent.CompletableFuture.uniApplyStage(CompletableFuture.java:658) at java.base/java.util.concurrent.CompletableFuture.thenApply(CompletableFuture.java:2094) at com.astrazeneca.vardict.modes.AbstractMode.pipeline(AbstractMode.java:48) at com.astrazeneca.vardict.modes.SimpleMode.processBamInPipeline(SimpleMode.java:103) at com.astrazeneca.vardict.modes.SimpleMode.access$000(SimpleMode.java:29) at com.astrazeneca.vardict.modes.SimpleMode$VardictWorker.call(SimpleMode.java:86) at com.astrazeneca.vardict.modes.SimpleMode$VardictWorker.call(SimpleMode.java:72) at java.base/java.util.concurrent.FutureTask.run(FutureTask.java:264) at java.base/java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1128) at java.base/java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:628) at java.base/java.lang.Thread.run(Thread.java:834)
Similar exceptions are repeated until we finally get:
VarDictJava fails (there were 11 continued exceptions during the run). Critical exception occurs on region: chr4:25001557-25001563, program will be stopped. java.util.concurrent.CompletionException: java.lang.RuntimeException: java.lang.IllegalArgumentException: Malformed CIGAR string: 68M1I-8M1I50M at java.base/java.util.concurrent.CompletableFuture.encodeThrowable(CompletableFuture.java:314) at java.base/java.util.concurrent.CompletableFuture.uniApplyNow(CompletableFuture.java:683) at java.base/java.util.concurrent.CompletableFuture.uniApplyStage(CompletableFuture.java:658) at java.base/java.util.concurrent.CompletableFuture.thenApply(CompletableFuture.java:2094) at com.astrazeneca.vardict.modes.AbstractMode.pipeline(AbstractMode.java:48) at com.astrazeneca.vardict.modes.SimpleMode.processBamInPipeline(SimpleMode.java:103) at com.astrazeneca.vardict.modes.SimpleMode.access$000(SimpleMode.java:29) at com.astrazeneca.vardict.modes.SimpleMode$VardictWorker.call(SimpleMode.java:86) at com.astrazeneca.vardict.modes.SimpleMode$VardictWorker.call(SimpleMode.java:72) at java.base/java.util.concurrent.FutureTask.run(FutureTask.java:264) at java.base/java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1128) at java.base/java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:628) at java.base/java.lang.Thread.run(Thread.java:834)
Using VarDict version 1.8.3 instead of the current 1.6.0 seems to fix the problem.
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