9 | | 1. If input tube content is DNA or RNA:[[BR]]a. Instead of a specimen item, a DNA extract or RNA extract item should be created.[[BR]]b. A DNA extract item from an input tube should have a name consisting of the case name followed by "`.d`", e.g. for case "`ML00001`" the DNA extract name will be "`ML00001.d`".[[BR]]c. An RNA extract item from an input tube should have a name consisting of the case name followed by "`.r`", e.g. for case "`ML00001`" the RNA extract name will be "`ML00001.r`".[[BR]]d. Currently annotation `SAMPLE_TYPE` ("`SampleType`") with possible value [`unknown`, `Primary tumour`, `Metastasis`, `DNA`, `RNA`] is used to indicate the input content of a specimen tube, and is stored both for the created case and child items. There are several problems with this; one is that the two options `Primary tumour` and `Metastasis` are intended for FFPE specimen items, another is that the name "`SampleType`" is inappropriate for DNA and RNA items, that are of type `Extract`, instead of `Sample`, like cases and specimens. Options [`unknown`, `Primary tumour`, `Metastasis`] should be stored in annotation of type `SPECIMEN_TYPE` ("`SpecimenType`") for specimen items, while a new annotation type `INPUT_TUBE_CONTENT_TYPE` ("`InputTubeContentType`") with options [`FFPE specimen`, `DNA`, `RNA`, `DNA + RNA`] should be created and stored with the created case item. |
| 9 | 1. If input tube content is DNA or RNA:[[BR]]a. Instead of a specimen item, a DNA extract or RNA extract item should be created.[[BR]]b. A DNA extract item from an input tube should have a name consisting of the case name followed by "`.d`", e.g. for case "`ML00001`" the DNA extract name will be "`ML00001.d`".[[BR]]c. An RNA extract item from an input tube should have a name consisting of the case name followed by "`.r`", e.g. for case "`ML00001`" the RNA extract name will be "`ML00001.r`".[[BR]]d. Currently annotation `SAMPLE_TYPE` ("`SampleType`") with possible value [`unknown`, `Primary tumour`, `Metastasis`, `DNA`, `RNA`] is used to indicate the input content of a specimen tube, and is stored both for the created case and child items. There are several problems with this; one is that the two options `Primary tumour` and `Metastasis` are intended for FFPE specimen items, another is that the name "`SampleType`" is inappropriate for DNA and RNA items, that are of type `Extract`, instead of `Sample`. Options [`unknown`, `Primary tumour`, `Metastasis`] should be stored in annotation of type `SPECIMEN_TYPE` ("`SpecimenType`") for specimen items, while a new annotation type `INPUT_TUBE_CONTENT_TYPE` ("`InputTubeContentType`") with options [`FFPE specimen`, `DNA`, `RNA`, `DNA + RNA`] should be created and stored with the created case item. |