Version 6 (modified by olle, 5 years ago) (diff)

Starting section 1.5 on pipeline management

MeLuDI Software Information

1 Introduction

1.1 Description

MeLuDI is an extension package to BASE with registration wizards for melanoma-lung cancer projects, in analogy with the package "Reggie" for the SCAN-B breast cancer project. It is named "MeLuDI" after "melanoma/lung cancer diagnostics". This page gives some background information on the software, and is not intended as a user manual. Instead, some behind-the-scene information is given, e.g. what item properties are used to track what steps in the lab processing pipeline an item has passed, which can be useful, if you want to check items for a specific step directly in BASE, or re-do a step, if an error occurred.

1.3 MeLuDI: The project, and MeLuDI: The software

"MeLuDI" (short for "melanoma/lung cancer diagnostics") is the name of a project at the Department of Oncology, Clinical Sciences, Lund University. It produces clinical genomics data from samples from patients having specific types of cancer, but also aims to support cancer research. Originally, the focus was on melanoma and lung cancer, but later on, more cancer types were supported. As part of the LIMS procedure, it was decided to store sample data in a database managed by BASE, and which normally was accessed through a BASE extension, named "MeLuDI" after the project. The software does not necessarily cover all aspects of the project, it was named after. However, when the name "MeLuDI" is used in this document without further specification, the reference is to the software.

1.4 Note on BASE annotations

BASE was developed to be a web-based interface to a database with bio assay data. In order to simplify adapting the software/database to specific data storage needs, a system of annotation types were developed, making it easy to add storage of new variable data to an "annotatable" item. An annotation type is of a specific data type, e.g. integer, float, string; and is defined for a specific type of item, e.g. samples, extracts, bioplates, item lists, etc.

1.5 Pipeline management

MeLuDI, like Reggie, is intended to simplify keeping track on what items are of interest in each step of the processing pipeline, e.g. by only including those item in selection menus for a particular step. In some cases, this is simple, since child items are created at registration in several steps, and will then be input items in the next step.